Coronavirus Outbreak [COVID-19]

Johnstown

Dominant Poster
Jun 4, 2013
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5,806
Hm, maybe we should continue trials on a certain drug and start halting mass gatherings, cough I mean unnecessary ones like protests/riots.
I assume you mean hydroxy...
There have been numerous studies already.

At this point giving more patients a drug that has proved time and again to be ineffectual and sometimes dangerous is bordering on malpractice.


As far as the protests go


They mostly are done in in most places (Oregon and a few other places being exceptions).
 
Jun 4, 2013
26,247
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I assume you mean hydroxy...
There have been numerous studies already.

At this point giving more patients a drug that has proved time and again to be ineffectual and sometimes dangerous is bordering on malpractice.


As far as the protests go


They mostly are done in in most places (Oregon and a few other places being exceptions).
Do you know how long clinical trials take or how many hospitals are involved? They involve a lot of time and a lot of money. On top of that, hydroxy is mixed with a cocktail of drugs. Another doctor in Houston doesn't seem to understand that a simple mongoloid on CHB knows a lot more than him.

“I use it for every patient,” said Dr. Varone at his north Houston medical facility, United Memorial Medical Center. “I have no problem telling people about this is a drug. I would take myself if I were to get ill and required to be in the hospital.”

Dr. Varon says he has experienced success in over 300 patients. The drug is a component in his recipe for success.

https://www.click2houston.com/news/investigates/2020/08/01/houston-area-doctor-agrees-with-use-of-controversial-drug-to-treat-covid-19/
 
Jun 4, 2013
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Now who should I listen to? The presidential medal of freedom winner or a 5'7 autistic man child who still lives with mommy and daddy and works as a teacher's aid part time and believes demons cause aids? @Mexi-Box
First off, he's not shutting down anything. He's pretty much just reiterating that he doesn't know and is looking forward to more studies. The drug, as the Congressman stated (being advised by doctors), are part of a cocktail of drugs. Just about every study I've seen talks about utilizing hydroxy with different drugs like azythromycin.

I'm slightly taller than Dr. Fauci too. Anyways, he's out of touch. A dinosaur, honestly. People like him need to start retiring and letting people like me start running shit. I think the fact that we have MD's running important regulatory sectors is one of the biggest hurdles in medical innovation.
 

Bachafach^^^

ANTIFA *funded by Soros*
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Do you know how long clinical trials take or how many hospitals are involved? They involve a lot of time and a lot of money. On top of that, hydroxy is mixed with a cocktail of drugs. Another doctor in Houston doesn't seem to understand that a simple mongoloid on CHB knows a lot more than him.

“I use it for every patient,” said Dr. Varone at his north Houston medical facility, United Memorial Medical Center. “I have no problem telling people about this is a drug. I would take myself if I were to get ill and required to be in the hospital.”

Dr. Varon says he has experienced success in over 300 patients. The drug is a component in his recipe for success.

https://www.click2houston.com/news/investigates/2020/08/01/houston-area-doctor-agrees-with-use-of-controversial-drug-to-treat-covid-19/
So if I had cancer and ate a jelly donut and suddenly had no cancer, does that mean jelly donuts cure cancer you micro dick autist?

You claim to be a scientist yet you don't know how science works. I don't even think you have the brain functionality to watch a class room while your teacher goes potty.
 
Jun 4, 2013
26,247
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So if I had cancer and ate a jelly donut and suddenly had no cancer, does that mean jelly donuts cure cancer you micro dick autist?

You claim to be a scientist yet you don't know how science works. I don't even think you have the brain functionality to watch a class room while your teacher goes potty.
:rofl

I answered that a long ass fucking time ago. FML, I guess no one really wants to come up with the facts but post memes and dumb snippets from Twatter. No, you fucking mongoloid. I already answered how medicines go into clinical trials.

First, a preclinical trial needs to occur, which shows that said drug or therapy works either in an animal model or cell culture. In some cases, orphan drugs or emergency drugs can be pushed through into clinical trials with cell culture experiments. I'm pretty sure all Sorrento had was cell culture and rushed through to clinical trials.

So yes, a jelly donut can go into clinical trials, but you would need to show that it works in a preclinical trial. That's directly through animal testing or cell culture. Make those keywords to follow for your tiny, pea-brain.

For hydroxy, the paper from 2005 whereby it stopped SARS is likely sufficient evidence to take it into a clinical trial. edit because some shitstain will say it's for SARS, not COVID-19: Oh, with how fucked up our clinical trials are and FDA putting more and more walls, if I ran the FDA, a phylogenetic link that exists within a certain threshold would be enough for me to push it through to clinical trials. I'll give an example. OGEN purchased the same mRNA Moderna utilizes, and they still had to show it works in preclinical. Waste of fucking time since I knew they would pass preclinicals with flying colors (they did). The SARS/MERS patent showed it worked well in mice, and I was fucking appalled that they even had to do preclinicals. I thought they were trying to get things through fast because we're facing a fucking pandemic! Anyways, just a quick rant about why we're still in the fucking dark-ages of medicine. (end edit)

Fuck me, I have to teach college students. I can't believe I'm wasting keystrokes trying to teach a bunch of imbred mongoloids that want to see people die because fuck Trump, that's why.

But yes, I don't know how science works.
 
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Bachafach^^^

ANTIFA *funded by Soros*
Dec 6, 2019
5,245
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Varaždin, Hrvaška
:rofl

I answered that a long ass fucking time ago. FML, I guess no one really wants to come up with the facts but post memes and dumb snippets from Twatter. No, you fucking mongoloid. I already answered how medicines go into clinical trials.
We are all aware what a clinical trial is you fucking midget.

Let's check your claim that

NIH halts clinical trial of hydroxychloroquine
Study shows treatment does no harm, but provides no benefit

A clinical trial to evaluate the safety and effectiveness of hydroxychloroquine for the treatment of adults hospitalized with coronavirus disease 2019 (COVID-19) has been stopped by the National Institutes of Health. A data and safety monitoring board (DSMB) met late Friday and determined that while there was no harm, the study drug was very unlikely to be beneficial to hospitalized patients with COVID-19. After its fourth interim analysis the DSMB, which regularly monitors the trial, recommended to the National Heart, Lung, and Blood Institute (NHLBI), part of NIH, to stop the study. NHLBI halted the trial immediately.

The Outcomes Related to COVID-19 treated with hydroxychloroquine among In-patients with symptomatic Disease study, or ORCHID Study, was being conducted by the Prevention and Early Treatment of Acute Lung Injury (PETAL) Clinical Trials Network of NHLBI. The data from this study indicate that this drug provided no additional benefit compared to placebo control for the treatment of COVID-19 in hospitalized patients.

The first participants enrolled in the trial in April at Vanderbilt University Medical Center, Nashville, Tennessee, one of dozens of centers in the PETAL Network. The blinded, placebo-controlled randomized clinical trial aimed to enroll more than 500 adults who are currently hospitalized with COVID-19 or in an emergency department with anticipated hospitalization. More than 470 were enrolled at the time of study’s closure.

All participants in the study received clinical care as indicated for their condition. Those randomized to the experimental intervention had also received hydroxychloroquine. Participants in the study will now continue to receive standard of care and follow up as indicated for their condition.

ORCHID participants had been randomly assigned to receive hydroxychloroquine 400 mg twice daily for two doses (day one), then 200 mg twice daily for the subsequent eight doses (days two to five) or a placebo twice daily for five days.

While COVID-19 usually presents as an acute respiratory infection, it can damage multiple organ systems, including heart, lung, and blood. Most adults with COVID-19 experience fever, cough, and fatigue and then recover within one to three weeks. However, some develop severe illness, typically manifesting as pneumonia and respiratory failure, with continued progression to acute respiratory distress syndrome and death.

Hydroxychloroquine is used to treat malaria and rheumatoid conditions such as arthritis. In various studies, the drug had demonstrated antiviral activity, an ability to modify the activity of the immune system, and it has an established safety profile at appropriate doses, leading to the hypothesis that it may have also been useful in the treatment of COVID-19.

Who
James P. Kiley, Ph.D., Director, Division of Lung Diseases, NHLBI, is available for interviews.

About the National Heart, Lung, and Blood Institute (NHLBI): NHLBI is the global leader in conducting and supporting research in heart, lung, and blood diseases and sleep disorders that advances scientific knowledge, improves public health, and saves lives. For more information, visit https://www.nhlbi.nih.gov/.

BIOPHARMA

Hydroxychloroquine flunks Phase III trial in mild-to-moderate Covid-19
The study adds to the growing body of evidence that the drug, promoted early in the pandemic by President Trump, is ineffective, despite its getting a briefly renewed lease on life earlier this month thanks to a retrospective analysis.
By ALARIC DEARMENT

30 Comments / Jul 26, 2020 at 11:00 AM

Results of new clinical trial published late last week have found that hydroxychloroquine – the malaria and autoimmune disease drug that President Donald Trump promoted as a potential “game changer” early in the Covid-19 pandemic – not only failed to improve outcomes in those with mild-to-moderate disease, but also produced a higher rate of cardiac and liver side effects.


Results of the randomized, controlled, open-label Phase III trial, which took place at more than two dozen sites in Brazil, were published in the New England Journal of Medicine on Thursday. The study randomized 667 patients to receive hydroxychloroquine or the drug plus the antibiotic azithromycin on top of standard of care or standard of care alone. When patients were measured on the seven-point ordinal scale of improvement in disease, those in the two hydroxychloroquine groups showed no improvement compared with patients who received standard of care alone. Moreover, those receiving hydroxychloroquine more frequently experienced Qt prolongation and elevation of liver enzymes.


First, a preclinical trial needs to occur, which shows that said drug or therapy works either in an animal model or cell culture. In some cases, orphan drugs or emergency drugs can be pushed through into clinical trials with cell culture experiments. I'm pretty sure all Sorrento had was cell culture and rushed through to clinical trials.








You're a fucking autistic virgin part time teachers aid that lives with mommy and daddy who I wouldn't let teach a monkey how to throw shit.
 
Jun 4, 2013
26,247
7,846
We are all aware what a clinical trial is you fucking midget.
So again, I read through some of the trial. They used hydroxy and azithromycin. I'm assuming they are following Dr. Rout's protocol. This seems to show that this particular combination might not work. According to the congressmen, doctors are using differing cocktail of drugs without a set standard. As Dr. Fauci mentioned in the Ford trial, they also used corticosteroids. Combination therapy with zinc, as one of the doctors put it, might also yield different, possibly more worthwhile results. Hell, combination with corticosteroids might also be the optimal treatment too.

This doesn't honestly put a nail through hydroxy altogether. Maybe it'd be worthwhile to also include zinc in the trial. With no optimal treatment available, it's still worth looking at hydroxy in all honesty. No other drug has been successful in preventing death, not even Remdesivir. Doctors are still currently using it and finding success. Again, we're at the same impasse. If I were heading this, I would definitely look at more cocktails that doctors are currently using.

Mortality was numerically lower in the remdesivir group than in the placebo group, but the difference was not significant (hazard ratio for death, 0.70; 95% CI, 0.47 to 1.04; 1059 patients).

https://www.nejm.org/doi/full/10.1056/NEJMoa2007764?query=featured_home

Remdesivir only shorts the duration of the virus, so again, without a treatment that will help those in the worst case-scenario, we still have to experiment. So again, Bachafag, how many more to that body count?
 
Jun 4, 2013
26,247
7,846
We'll see if I ever offer you my cocktail of fruitrollups and jelly donuts when you get cancer.
:rofl just read my post and then give me specifics on it. Challenge me on why we should stop all clinical trials on hydroxy. I'd love to hear what you have to say as someone with a robust, worthless knowledge of SJW-isms. Very likely, I'm going to get a, "Gorumph bad, Gorumph said drug good, so drug bad."
 

Bachafach^^^

ANTIFA *funded by Soros*
Dec 6, 2019
5,245
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Varaždin, Hrvaška
So again, I read through some of the trial. They used hydroxy and azithromycin. I'm assuming they are following Dr. Rout's protocol. This seems to show that this particular combination might not work. According to the congressmen, doctors are using differing cocktail of drugs without a set standard. As Dr. Fauci mentioned in the Ford trial, they also used corticosteroids. Combination therapy with zinc, as one of the doctors put it, might also yield different, possibly more worthwhile results. Hell, combination with corticosteroids might also be the optimal treatment too.
Yes you stupid fuck we get it, your cop out for the numerous studies Hydroxy does not work is that it had to be used with tons of other drugs, some specific some not so specific and then maybe you dont die and have heart disease for the rest of your life.

Do you know how stupid you sound pretend scientist? That we should start dosing people up with all combinations of drugs. Do you think that would make it to clinical trial? Derr add some zinc, and fuck it, sprinkle some melotonin in there, lets get funky.


Yes we are at an impasse, you're a fucking idiot.
 

Bachafach^^^

ANTIFA *funded by Soros*
Dec 6, 2019
5,245
4,026
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Varaždin, Hrvaška
:rofl just read my post and then give me specifics on it. Challenge me on why we should stop all clinical trials on hydroxy. I'd love to hear what you have to say as someone with a robust, worthless knowledge of SJW-isms. Very likely, I'm going to get a, "Gorumph bad, Gorumph said drug good, so drug bad."
Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19
List of authors.
  • Alexandre B. Cavalcanti, M.D., Ph.D.,
  • Fernando G. Zampieri, M.D., Ph.D.,
  • Regis G. Rosa, M.D., Ph.D.,
  • Luciano C.P. Azevedo, M.D., Ph.D.,
  • Viviane C. Veiga, M.D., Ph.D.,
  • Alvaro Avezum, M.D., Ph.D.,
  • Lucas P. Damiani, M.Sc.,
  • Aline Marcadenti, Ph.D.,
  • Letícia Kawano-Dourado, M.D., Ph.D.,
  • Thiago Lisboa, M.D., Ph.D.,
  • Debora L. M. Junqueira, M.D.,
  • Pedro G.M. de Barros e Silva, M.D., Ph.D.,























  • et al.,
  • for the Coalition Covid-19 Brazil I Investigators*
Metrics
Abstract
BACKGROUND

Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety and efficacy of these therapies is limited.
METHODS
We conducted a multicenter, randomized, open-label, three-group, controlled trial involving hospitalized patients with suspected or confirmed Covid-19 who were receiving either no supplemental oxygen or a maximum of 4 liters per minute of supplemental oxygen. Patients were randomly assigned in a 1:1:1 ratio to receive standard care, standard care plus hydroxychloroquine at a dose of 400 mg twice daily, or standard care plus hydroxychloroquine at a dose of 400 mg twice daily plus azithromycin at a dose of 500 mg once daily for 7 days. The primary outcome was clinical status at 15 days as assessed with the use of a seven-level ordinal scale (with levels ranging from one to seven and higher scores indicating a worse condition) in the modified intention-to-treat population (patients with a confirmed diagnosis of Covid-19). Safety was also assessed.
RESULTS
A total of 667 patients underwent randomization; 504 patients had confirmed Covid-19 and were included in the modified intention-to-treat analysis. As compared with standard care, the proportional odds of having a higher score on the seven-point ordinal scale at 15 days was not affected by either hydroxychloroquine alone (odds ratio, 1.21; 95% confidence interval [CI], 0.69 to 2.11; P=1.00) or hydroxychloroquine plus azithromycin (odds ratio, 0.99; 95% CI, 0.57 to 1.73; P=1.00). Prolongation of the corrected QT interval and elevation of liver-enzyme levels were more frequent in patients receiving hydroxychloroquine, alone or with azithromycin, than in those who were not receiving either agent.
CONCLUSIONS
Among patients hospitalized with mild-to-moderate Covid-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care. (Funded by the Coalition Covid-19 Brazil and EMS Pharma; ClinicalTrials.gov number, NCT04322123. opens in new tab.)
 
Jun 4, 2013
26,247
7,846
Yes you stupid fuck we get it, your cop out for the numerous studies Hydroxy does not work is that it had to be used with tons of other drugs, some specific some not so specific and then maybe you dont die and have heart disease for the rest of your life.

Do you know how stupid you sound pretend scientist? That we should start dosing people up with all combinations of drugs. Do you think that would make it to clinical trial? Derr add some zinc, and fuck it, sprinkle some melotonin in there, lets get funky.


Yes we are at an impasse, you're a fucking idiot.
Cop out? :rofl

I just fucking laid it out to you, completely destroyed it, and you're calling it a cop out? Fuck me, you can't even back up your shit except a bunch of grandstanding and childish name calling.

Again, doctors are using it with a non-standard cocktail. This isn't me hypothesizing. This is real-life doctors. It is worth it to take through clinical trials because, again, tell me specifically what we can do in the meantime, Bachafag? Do we just halt all testing altogether even though doctors are finding success with this assortment? Thank goodness you are nowhere near where you can have any effect on this. Exactly why a drug shouldn't be politicized. We have retards like yourself who have no fucking clue how shit works trying to play expert.

Again, give me insight as to what we should do when doctors are hailing a cocktail of drugs working? Should we just ignore it because one clinical trial failed with a totally different combination?

By the way, here is a study where remdesivir, the current gold standard, failed.

Remdesivir was stopped early because of adverse events in 18 (12%) patients versus four (5%) patients who stopped placebo early.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31022-9/fulltext

Hm, did we halt all remdesivir trials after this? Answer me, give me specifics.
 

Bachafach^^^

ANTIFA *funded by Soros*
Dec 6, 2019
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Varaždin, Hrvaška
Cop out? :rofl

I just fucking laid it out to you, completely destroyed it, and you're calling it a cop out? Fuck me, you can't even back up your shit except a bunch of grandstanding and childish name calling.
bryan
Look a the virgin who still lives with daddy and mommy who runs around calling people swollenanus calling someone childish. You're crying because you're being made to look like a fool and your whole charade of pretending to be a scientist when at best you are a glorified teachers aide is unraveling.

Again, doctors are using it with a non-standard cocktail. This isn't me hypothesizing. This is real-life doctors. It is worth it to take through clinical trials because, again, tell me specifically what we can do in the meantime,
Who gives a fuck what some doctors are using to treat the drug. Thats not how science is conducted you fucking moron. Whenever Hydroxy is tested it fails, when is tested with other drugs like Azithromycin it fails. What are you going to do, run the gamut of injecting people with all combinations of drugs hoping for success. Is that how science works you fucking idiot. You hope something works without any evidence to back it up. That we should take a list of drugs proscribed by a doctor who claims 300 people lived without long term monitoring or even consideration of side effects? Are you fucking mad?

Here a nursing home proscribed "covid cocktails" and guess what dozens of people fucking died. Some died who we dont even know had Covid. But yes lets start dosing people with random shit even though study after study conducted so far shows it does not fucking work.

https://www.washingtonpost.com/business/2020/07/07/covid-cocktail-inside-pa-nursing-home-that-gave-some-veterans-hydroxychloroquine-even-without-covid-19-testing/

Get off world of warcraft and stop burdening your parents.