I never would have thought about it before this thread but like others I'd grab my portable hard drive. Far to many photos from life through the years on it that I haven't saved anywhere else to let it go.
Also I have a watch that was the last thing my pop gave to me before he passed. It's nothing fancy just a cheap one he won in a golf comp but it's a sentimental gift.
A blanket, same kind of thing but was the last thing my nan gave to me before she lost herself to dementia and eventually passed.
An indigenous spear I have hanging in the lounge room, A painting I was gifted right under it.
Other than that I wouldn't risk it. Everything else is replaceable.
Oh... just to add Since the watch is in the same draw and container thing, I'd grab mine an and my missos passports and a few ID docs. Having to replace those and the visa's etc would be a nightmare.
I'm pretty confident I could carry all that and round it up within a min or two max.